Predicted Entities,flag,username,timestamp
"[{""token"": ""\nDr. "", ""class_or_confidence"": null}, {""token"": ""Paul Hammond"", ""class_or_confidence"": ""neurologist""}, {""token"": "", a renowned neurologist at "", ""class_or_confidence"": null}, {""token"": ""Johns Hopkins University"", ""class_or_confidence"": ""university""}, {""token"": "", has recently published a paper in the prestigious journal \"""", ""class_or_confidence"": null}, {""token"": ""Nature Neuroscience"", ""class_or_confidence"": ""journal""}, {""token"": ""\"". His research focuses on a rare "", ""class_or_confidence"": null}, {""token"": ""genetic mutation"", ""class_or_confidence"": ""biological process""}, {""token"": "", found in less than 0.01% of the population, that appears to prevent the development of "", ""class_or_confidence"": null}, {""token"": ""Alzheimer's disease"", ""class_or_confidence"": ""disease""}, {""token"": "". Collaborating with researchers at the "", ""class_or_confidence"": null}, {""token"": ""University of California"", ""class_or_confidence"": ""university""}, {""token"": "", "", ""class_or_confidence"": null}, {""token"": ""San Francisco"", ""class_or_confidence"": ""city""}, {""token"": "", the team is now working to understand the mechanism by which this mutation confers its protective effect. Funded by the "", ""class_or_confidence"": null}, {""token"": ""National Institutes of Health"", ""class_or_confidence"": ""university""}, {""token"": "", their research could potentially open new avenues for Alzheimer's treatment.\n"", ""class_or_confidence"": null}]",,,2024-05-31 21:19:47.389544
"[{""token"": ""\n\""I recently purchased the "", ""class_or_confidence"": null}, {""token"": ""Sony WH-1000XM4 Wireless Noise-Canceling Headphones"", ""class_or_confidence"": ""product""}, {""token"": "" from "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "" and I must say, I'm thoroughly impressed. The package arrived in "", ""class_or_confidence"": null}, {""token"": ""New York"", ""class_or_confidence"": ""location""}, {""token"": "" within 2 days, thanks to "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "" Prime's expedited shipping.\n\nThe headphones themselves are remarkable. The "", ""class_or_confidence"": null}, {""token"": ""noise-canceling feature"", ""class_or_confidence"": ""features""}, {""token"": "" works like a charm in the bustling city environment, and the "", ""class_or_confidence"": null}, {""token"": ""30-hour battery life"", ""class_or_confidence"": ""features""}, {""token"": "" means I don't have to charge them every day. Connecting them to my "", ""class_or_confidence"": null}, {""token"": ""Samsung Galaxy S21"", ""class_or_confidence"": ""product""}, {""token"": "" was a breeze, and the sound quality is second to none.\n\nI also appreciated the customer service from "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "" when I had a question about the warranty. They responded within an hour and provided all the information I needed.\n\nHowever, the "", ""class_or_confidence"": null}, {""token"": ""headphones"", ""class_or_confidence"": ""product""}, {""token"": "" did not come with a hard case, which was listed in the product description. I contacted "", ""class_or_confidence"": null}, {""token"": ""Amazon"", ""class_or_confidence"": ""brand""}, {""token"": "", and they offered a 10% discount on my next purchase as an apology.\n\nOverall, I'd give these headphones a "", ""class_or_confidence"": null}, {""token"": ""4.5/5"", ""class_or_confidence"": ""rating""}, {""token"": "" rating and highly recommend them to anyone looking for top-notch quality in both product and service."", ""class_or_confidence"": null}]",,,2024-05-31 21:19:49.044543
"[{""token"": ""\nSeveral studies have reported its pharmacological activities, including anti-inflammatory, antimicrobial, and antitumoral effects.\nThe effect of E-anethole was studied in the osteosarcoma "", ""class_or_confidence"": null}, {""token"": ""MG-63 cell line"", ""class_or_confidence"": ""cell line""}, {""token"": "", and the antiproliferative activity was evaluated by an MTT assay.\nIt showed a "", ""class_or_confidence"": null}, {""token"": ""GI50"", ""class_or_confidence"": ""metric""}, {""token"": "" value of 60.25 \u03bcM with apoptosis induction through the mitochondrial-mediated pathway. Additionally, it induced cell cycle arrest at the G0/G1 phase, up-regulated the expression of p53, caspase-3, and caspase-9, and down-regulated Bcl-xL expression.\nMoreover, the antitumoral activity of anethole was assessed against oral tumor "", ""class_or_confidence"": null}, {""token"": ""Ca9-22 cells"", ""class_or_confidence"": ""cell line""}, {""token"": "", and the cytotoxic effects were evaluated by MTT and LDH assays.\nIt demonstrated a "", ""class_or_confidence"": null}, {""token"": ""LD50"", ""class_or_confidence"": ""metric""}, {""token"": "" value of 8 \u03bcM, and cellular proliferation was 42.7% and 5.2% at anethole "", ""class_or_confidence"": null}, {""token"": ""concentrations"", ""class_or_confidence"": ""metric""}, {""token"": "" of 3 \u03bcM and 30 \u03bcM, respectively.\nIt was reported that it could selectively and in a dose-dependent manner decrease cell proliferation and induce apoptosis, as well as induce autophagy, decrease ROS production, and increase glutathione activity. The cytotoxic effect was mediated through NF-kB, MAP kinases, Wnt, caspase-3 and -9, and PARP1 pathways. Additionally, treatment with anethole inhibited cyclin D1 oncogene expression, increased cyclin-dependent kinase inhibitor "", ""class_or_confidence"": null}, {""token"": ""p21WAF1"", ""class_or_confidence"": ""protein""}, {""token"": "", up-regulated p53 expression, and inhibited the EMT markers.\n"", ""class_or_confidence"": null}]",,,2024-05-31 21:19:51.221542