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Researchers receive $3.75 million to study the impact of fluid flow on CAR-T cell therapy for brain cancer
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Caribou Bio Secures $115M to Advance CRISPR Platform and Allogeneic Cell Therapy Pipeline
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image of a T-cell
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The dark side of stem cell therapy
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Novartis to Seek Approval by Year’s End to Test Gene Therapy Candidate
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Novartis Receives EU Approval for Gene Therapy Luxturna (voretigene neparvovec) in Patients with Rare Inherited Retinal Disease
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div class='caption-body'><ul class ='image_legend_ul'> Tetrameric assembly 1 of PDB entry 2ypb coloured by chemically distinct molecules and viewed from the side. This assembly contains:<li class ='image_legend_li'>One copy of T-cell acute lymphocytic leukemia protein 1</li><li class ='image_legend_li'>One copy of Transcription factor E2-alpha</li><li class ='image_legend_li'>One copy of EBOX FORWARD</li><li class ='image_legend_li'>One copy of EBOX REVERSE</li></ul></div
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Cell and Gene Therapy Programs
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CAR-T therapies: the future of cancer care, or an industry pipe dream?
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Gene therapy shows promise in initial trial for patients with childhood blindness
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MHH: New test to make gene therapy safer
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Stem cell therapy involves harvesting stem cells from other parts of the body and injecting them directly into the injured joint
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Cell & Gene Therapy
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CAR T-cells may be useful in the fight against the coronavirus
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Induced Stem-Cells for Gene Therapy
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pool supply world t-cell 15 replacement salt cell
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gene therapy essay expert academic writing help you will prefer edwina 28 2017 gene therapy essay jpg
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Virology and gene therapy research trainee
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Town Hall Briefing: Gene Therapy and Sickle Cell Disease tickets
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Pfizer Launches Phase 1b Clinical Trial for Mini-Dystrophin Gene Therapy to Treat DMD
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Gene Therapy Protocols: Volume 2: Design and Characterization of Gene Transfer Vectors: Design and Characterization of Gene Transfer Vectors v. 2 (Methods in Molecular Biology
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view Cell Therapy for Brain Injury
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Cancerwise blog: Borje S. Andersson, M.D., Ph.D., specializes in stem cell transplants, including autologous and allogeneic stem cell transplants, at MD Anderson Cancer Center
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div class='caption-body'><ul class ='image_legend_ul'> Dimeric assembly 1 of PDB entry 1jnp coloured by chemically distinct molecules and viewed from the top. This assembly contains:<li class ='image_legend_li'>2 copies of T-cell leukemia/lymphoma protein 1A</li></ul></div
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Image of ELISA kit for Porcine I-TAC/CXCL11 (Interferon Inducible T-cell Alpha Chemoattractant
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telomegenase, testimonial, reviews, cell therapy, anti-aging, telomerase, telomere supplement, Dr. Edward Chan
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How does stem cell therapy make you feel?
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The effects of gene therapy
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Regulatory T-cell or Tregs usually act as brakes in our immune system
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Figure 5: Images from the cancer-art collaborative project – “Cancer: Finding Beauty in the Beast”, from top left, clockwise, “Energy flow”, oil on yupo paper (©2014 Caroline Shaw Ometz), “Will there be anything left of me”, digital photography (©2015 Sandra Freeman), “T-cells attacking C-cells”, watercolor on yupo paper (©2015 Elisabeth Schalij), “Internal Space”, oil on panel (©2014 Puneeta Mittal), “Symmetry-transition-entropy”, kiln-formed art glass (©2015 Anne Neal), and “Strange attractor of cancer in its phase space”, acrylic on paper and Adobe illustrator (©2014 Dhruba Deb
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ahairlosscureHair Loss Stem Cell Therapy
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Roche to accelerate position in gene therapy with Spark acquisition
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Machine learning used to generate AAV capsids for gene therapy
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Gene Therapy Improves the Brains of Mice With Alzheimer’s
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Baby Face Cell Therapy - Eunogo Shop
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ASCO 2020: Adoptive T-cell therapy ADP-A2M4 targeting MAGE-A4 shows early activity in patients with advanced solid tumours
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regenerative and cell therapy clinical advances ernst schering research foundation workshop supplement 11 2004
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A good glimpse on cell therapy efforts ongoing in oncology
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Cell and Gene Therapy: Heatmap and Industry Update 2019
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Amazing Results For Stem Cell Therapy In Pets
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Illustration of how gene therapy works. The normal gene copy is transported by a modified virus to the affected cell. Once inside the cell, the normal gene copy provides the correct instructions for protein production, replacing the mutated gene.
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Research At CSU Suggests Stem Cell Therapy Beneficial To Cats In Chronic Kidney Failure
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div class='caption-body'><ul class ='image_legend_ul'>The deposited structure of PDB entry 1jnp coloured by chain and viewed from the side. The entry contains: <li class ='image_legend_li'>2 copies of T-cell leukemia/lymphoma protein 1A</li><li class ='image_legend_li'>There are no non-polymeric molecules</li></ul></li></ul></li></div
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Shire’s Experimental Gene Therapy Delivery Strategies Show Potential for Hemophilia A and B
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ASGCT 2020 Abstract:Lentiviral Gene Therapy for Hemophilia B: Exploration of Endothelial Promoters in Mesenchymal Stem Cells
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shop Gene Therapy
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Cell Therapy - Lineage Cell Therapeutics
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Nature: What challenges for CAR-T therapy when treating solid tumors?
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download gene therapy and tissue engineering in orthopaedic and
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Amicus Shells Out $100M For Celenex And Dives Into Gene Therapy
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Gene therapy effective for treating macular degeneration: Study
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FDA’s Pursuit in Progressing Gene Therapy While Maintaining Safety
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Diagram showing how gene therapy puts the gene into the cell to alter its DNA
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Dr Jacqueline Barry, Chief Clinical Officer, Cell and Gene Therapy Catapult
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🎤 Goodie Mob - Soul Food / Cell Therapy MP3
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UltiMapper I/O PD-L1 kit staining of macrophages and cytotoxic t-cells in non-small cancer lung tissue.
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Stem Cell Therapy: A Rising Tide: How Stem Cells Are Disrupting Medicine and Transforming Lives cover
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Lentiviral vector delivery of hIL-7 promotes homeostatic proliferation of adoptively transferred human T cells in Rag2-/-γc-/- mice. a. Serum concentrations of hIL-7 detected by ELISA three weeks after intravenous administration of 9×10 7 or 1.7×10 8 IU of lentivirus expressing either luciferase or hIL-7. b. The percentage of CD3+, CD4+ or CD8+ T cells of live splenocytes following one week post transfer of 2×10 7 CFSE labeled human PBMCs into Rag2-/-γc-/- mice from A. c. Average mean fluorescence intensity (MFI) of CFSE measured by flow cytometry in T-cell subsets quantified in B. Four mice were used per group, and the average and SEM are shown. d. Representative histograms showing CFSE loss by CD3+, CD4+ or CD8+ adoptively transferred T cells from mice receiving the control vector, low dose hIL-7 or high dose hIL-7.
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0.00363
0.012836
0.000428
4.127588
1,443,109,372,145
https://www.codingahead.…1/13-768x437.jpg
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768
437
f169c686ce4cce92
73
8
15
14
1
0.230957
0.144653
0.001938
0.010679
0.876043
5.421049
463,856,580,948
https://infinityclinic.c…/image/prevv.jpg
Stem cell therapy for lung fibrosis
1,500
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e1d1964e8e3d58c6
35
6
8
8
0
0.291016
0.269287
0.00663
0.040946
0.97411
5.574659
360,777,936,338
https://mdnewsline.com/w…nts-Leukemia.jpg
Gene Therapy for Sickle Cell Did Not Cause Patient’s Leukemia
625
350
c1c3661c9d3e361e
61
11
13
15
0
0.320557
0.283447
0.000769
0.013304
0.058433
5.279602
1,400,160,029,310
https://m.media-amazon.c…C_UY218_ML3_.jpg
Optimum Pool Technologies Simple Cell Replacement T-Cell-15 Salt Cell Up to 40,000 Gallon
583
218
e0e89f14951ff08e
89
16
20
21
0
0.250977
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4.443345
7,636,452,440,403
https://i1.abocdn.com/productimage/v6795250e/u0h15l7b4a1x/?w=300&h=200
Image no. 2 for anti-Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7) (AA 287-384) antibody (ABIN520773
300
200
bea56d94c3bc8039
111
19
42
39
0
0.338867
0.245361
0.000518
0.016199
0.057096
4.238019
455,266,899,758
https://cells4life.com/w…virus-blog-2.png
coronavirus treatment using umbilical cord stem cell therapy
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675
b1f2d3b30e12e46c
60
8
11
13
0
0.29126
0.249146
0.023315
0.027006
0.34847
5.000208
5,076,651,499,763
https://hollyswellness.c…0000-600x600.png
 Relumins Advance White Stem Cell Therapy All in One Day Lotion 
600
600
e6cc983399699966
64
11
14
17
0
0.270996
0.278564
0.000394
0.012352
0.08873
4.538412
7,696,581,743,764
https://i2.wp.com/innova…=610%2C380&ssl=1
Imagine using gene therapy to correct lethal lung diseases before death
610
380
8ebcdd1b9c463816
71
11
11
11
0
0.268066
0.212524
0.007374
0.011635
0.006599
4.714053
5,557,688,087,321
https://diabetestalk.net…xESWupUIIcsz.jpg
Gene Therapy Temporarily Reverses Type 1 Diabetes In Mice
800
400
9987f2e827d207b2
57
9
10
14
0
0.291748
0.254395
0.005062
0.036017
0.125781
4.128995
5,171,140,968,276
https://wid.wisc.edu/wp-…x480-444x250.jpg
UW Researchers Partner with US Department of Defense to Develop Stem Cell Therapy for Combat-Related Eye Injuries
444
250
eeba510b64517f12
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18
20
22
0
0.205322
0.238037
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5,368,709,609,335
https://www.europeanphar…613734957884.jpg
DNA double helix in blue with a specific region (gene) highlighted in yellow - idea of gene therapy
750
563
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17
20
22
1
0.288086
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5.422073
5,360,119,550,275
https://naes.unr.edu/bar…0_a-1024x818.jpg
Pro gene therapy essay
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4
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0.17627
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https://pharmaphorum.com…00-1-600x340.jpg
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600
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9
9
9
0
0.23999
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4.408872
7,121,056,125,382
https://www.medhaavi.in/…001-1024x864.png
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1,024
864
aa1e330e4cb6f4a6
35
6
6
7
0
0.286133
0.279297
0.006649
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5.204457
4,406,636,780,025
https://media.gettyimages.com/videos/tcell-medical-illustration-video-id537852616?s=640x640
t-cell medical illustration - biology stock videos & royalty-free footage
640
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c4b57c0e7b30313b
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10
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0.308105
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0.0023
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0.6506
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6,837,588,500,886
https://www.bioagilytix.…mmunotherapy.jpg
CAR T-Cell Therapy: Changing the Way Cancer is Treated
800
280
d28c99f0276f32b1
54
10
12
13
0
0.243164
0.227295
0.050385
0.105355
0.389989
5.052741
4,621,385,428,864
https://cdn-6003fd83c1ac…76-1-400x225.jpg
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400
225
9469262731596fbc
60
8
14
15
0
0.301514
0.259766
0.000851
0.009208
0.535235
5.502511
2,637,110,401,508
https://www.pureacufl.co…cell-therapy.jpg
Boca Raton Stem Cell Therapy
2,048
2,048
ad9a14bc2b742b36
28
5
6
8
2
0.27417
0.213379
0.000363
0.053876
0.067281
4.986169
5,076,651,572,612
https://mk0labiotecheugl…p_-CI-Photos.jpg
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800
275
9ec2e14d6ab1cdc2
77
11
20
17
0
0.286621
0.269531
0.036377
0.113432
0.463287
5.460395
3,238,406,103,838
https://cdn.snapi.dev/im…ech29-701321.jpg
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640
360
d8b3c5ccc0c0f95b
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11
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0.269531
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0.008995
0.027913
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5.343158
1,692,217,589,893
https://i1.abocdn.com/productimage/v825af001/e1l87k1f3h4l/?w=300&h=200
Image no. 2 for anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) (C-Term) antibody (ABIN2792541
300
200
ba726d66954b2435
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16
35
36
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0.333252
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0.211846
4.588634
2,551,210,750,468
https://photos.smugmug.c…17SITC_395-M.jpg
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927ec11d618f1ce3
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24
43
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1
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7,361,574,452,968
https://thumbnails.yayim…/3fe/63fe3e8.jpg
Royalty free image of Doctor shows information: stem cell therapy by gwolters
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0.333008
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1,606,317,965,875
https://adrenoleukodystr…724-1400x480.jpg
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1,400
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9
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0.272461
0.217285
0.016739
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6,150,393,491,832
https://inicop.org/image…go/14570/550.jpg
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200
c16b169646697a9e
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0.018173
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2,379,412,393,095
https://www.abbexa.com/i…2_IF-250x250.jpg
T-Cell Leukemia/lymphoma Protein 1A (TCL1A) Antibody
250
250
bb382a3ca76b2079
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8
18
21
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0.313965
0.235962
0.000363
0.007637
0.035642
3.989718
7,249,905,131,355
https://cdn.awsli.com.br…kit-4f6ae4d8.jpg
Mouse I-TAC/CXCL11(Interferon Inducible T-Cell Alpha Chemoattractant) ELISA Kit
300
209
af877892204cf96b
79
12
29
30
0
0.342285
0.337158
0.050659
0.027084
0.00354
3.853149
7,043,746,764,565
https://d3re0f381bckq9.c…s-30_783x391.jpg
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783
391
ed72d14d8aa6828f
33
5
8
9
1
0.30249
0.289307
0.00349
0.021038
0.04448
4.584871
137,439,376,551
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440
248
c0c31b3fbc5a4aa5
116
17
27
29
0
0.336426
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0.001015
0.00267
0.11279
4.821657
7,258,495,244,966
https://musculardystroph…157-1000x480.jpg
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1,000
480
acc8c6e397b909cc
69
10
16
18
1
0.285889
0.242432
0.003069
0.077636
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4.89712
2,594,160,912,643
https://www.pharmaceutic…White-Papers.jpg
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256
200
c3e1b70ba52445fa
81
10
16
18
0
0.24585
0.179321
0.007164
0.081355
0.952738
4.474554
3,169,686,434,473
https://mma.prnewswire.com/media/739263/Novartis_Pharmaceuticals_Canada_Inc__Novartis_receives_Health_Ca.mp4?p=medium
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512
288
85d078a57e0f876a
44
7
12
13
0
0.285156
0.266846
0.00856
0.014771
0.429415
4.010285
3,865,470,661,908
https://www.medacess.com…ophy_yy5xy0.webp
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1,200
792
bc1ec2e3851d92e9
41
7
9
12
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0.301514
0.247314
0.014702
0.033429
0.124817
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5,317,169,916,210
https://storage.googleap…1004287.g003.jpg
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742
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8e8545d6f9955aa4
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153
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4.289151
652,835,193,155
https://www.firstpost.co…20_Watermark.jpg
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220
220
bc24c15ae3dbc899
71
10
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13
0
0.258301
0.2229
0.004555
0.021544
0.081962
4.566023
8,486,855,811,889
https://static1.bigstock…e2/377951890.jpg
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450
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fcd183169968d725
100
18
21
24
0
0.287598
0.259033
0.061829
0.361984
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4.098097
7,980,049,550,579
https://www.osservatorio…urce-def-min.png
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250
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4
4
4
2
0.258057
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0.011627
0.011664
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2,680,060,268,240
https://www.rapmusicguid…cell-therapy.jpg
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400
394
d7b17cc04ac2079f
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4
6
6
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0.376709
0.383057
0.000616
0.01754
0.044837
4.688567
5,488,968,298,901
https://healthandwellnes…-it--300x203.jpg
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8191f8f0269c5bb7
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11
12
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0
0.280518
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0.064026
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0.299552
4.953664
8,744,553,843,544
https://d3a9idtyc0vr09.c…5017-272x305.jpg
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272
305
d82cbc06aff16689
68
11
12
16
1
0.271973
0.192505
0.005878
0.139401
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5.813724
7,722,351,459,737
https://images.slideplay…ides/slide_2.jpg
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720
ea37156e164b4b15
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28
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https://newsroom.unsw.ed…pg?itok=myb_wq4O
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Dataset Card for filterred-coyo-700M-beta

Dataset Summary

Supported Tasks and Leaderboards

Languages

The texts in the COYO-700M dataset consist of English.

Dataset Structure

Data Instances

Each instance in COYO-700M represents single image-text pair information with meta-attributes:

{
  'id': 841814333321,
  'url': 'https://blog.dogsof.com/wp-content/uploads/2021/03/Image-from-iOS-5-e1614711641382.jpg',
  'text': 'A Pomsky dog sitting and smiling in field of orange flowers',
  'width': 1000,
  'height': 988,
  'image_phash': 'c9b6a7d8469c1959',
  'text_length': 59,
  'word_count': 11,
  'num_tokens_bert': 13,
  'num_tokens_gpt': 12,
  'num_faces': 0,
  'clip_similarity_vitb32': 0.4296875,
  'clip_similarity_vitl14': 0.35205078125,
  'nsfw_score_opennsfw2': 0.00031447410583496094,
  'nsfw_score_gantman': 0.03298913687467575,
  'watermark_score': 0.1014641746878624,
  'aesthetic_score_laion_v2': 5.435476303100586
}

Data Fields

name type description
id long Unique 64-bit integer ID generated by monotonically_increasing_id()
url string The image URL extracted from the src attribute of the <img> tag
text string The text extracted from the alt attribute of the <img> tag
width integer The width of the image
height integer The height of the image
image_phash string The perceptual hash(pHash) of the image
text_length integer The length of the text
word_count integer The number of words separated by spaces.
num_tokens_bert integer The number of tokens using BertTokenizer
num_tokens_gpt integer The number of tokens using GPT2TokenizerFast
num_faces integer The number of faces in the image detected by SCRFD
clip_similarity_vitb32 float The cosine similarity between text and image(ViT-B/32) embeddings by OpenAI CLIP
clip_similarity_vitl14 float The cosine similarity between text and image(ViT-L/14) embeddings by OpenAI CLIP
nsfw_score_opennsfw2 float The NSFW score of the image by OpenNSFW2
nsfw_score_gantman float The NSFW score of the image by GantMan/NSFW
watermark_score float The watermark probability of the image by our internal model
aesthetic_score_laion_v2 float The aesthetic score of the image by LAION-Aesthetics-Predictor-V2

Data Splits

Data was not split, since the evaluation was expected to be performed on more widely used downstream task(s).

Dataset Creation

Curation Rationale

Similar to most vision-and-language datasets, our primary goal in the data creation process is to collect many pairs of alt-text and image sources in HTML documents crawled from the web. Therefore, We attempted to eliminate uninformative images or texts with minimal cost and improve our dataset's usability by adding various meta-attributes. Users can use these meta-attributes to sample a subset from COYO-700M and use it to train the desired model. For instance, the num_faces attribute could be used to make a subset like COYO-Faces and develop a privacy-preserving generative model.

Source Data

Initial Data Collection and Normalization

We collected about 10 billion pairs of alt-text and image sources in HTML documents in CommonCrawl from Oct. 2020 to Aug. 2021. and eliminated uninformative pairs through the image and/or text level filtering process with minimal cost.

Image Level

  • Included all image formats that Pillow library can decode. (JPEG, WEBP, PNG, BMP, ...)
  • Removed images less than 5KB image size.
  • Removed images with an aspect ratio greater than 3.0.
  • Removed images with min(width, height) < 200.
  • Removed images with a score of OpenNSFW2 or GantMan/NSFW higher than 0.5.
  • Removed all duplicate images based on the image pHash value from external public datasets.
    • ImageNet-1K/21K, Flickr-30K, MS-COCO, CC-3M, CC-12M

Text Level

  • Collected only English text using cld3.
  • Replaced consecutive whitespace characters with a single whitespace and removed the whitespace before and after the sentence. (e.g. "\n \n Load image into Gallery viewer, valentine&amp;#39;s day roses\n \n" → "Load image into Gallery viewer, valentine&amp;#39;s day roses")
  • Removed texts with a length of 5 or less.
  • Removed texts that do not have a noun form.
  • Removed texts with less than 3 words or more than 256 words and texts over 1000 in length.
  • Removed texts appearing more than 10 times. (e.g. “thumbnail for”, “image for”, “picture of”)
  • Removed texts containing NSFW words collected from profanity_filter, better_profanity, and google_twunter_lol.

Image-Text Level

  • Removed duplicated samples based on (image_phash, text). (Different text may exist for the same image URL.)

Who are the source language producers?

Common Crawl is the data source for COYO-700M.

Annotations

Annotation process

The dataset was built in a fully automated process that did not require human annotation.

Who are the annotators?

No human annotation

Personal and Sensitive Information

Disclaimer & Content Warning

Considerations for Using the Data

Social Impact of Dataset

Discussion of Biases

Other Known Limitations

Additional Information

Dataset Curators

Licensing Information

License

The COYO dataset of Kakao Brain is licensed under CC-BY-4.0 License. The full license can be found in the LICENSE.cc-by-4.0 file. The dataset includes “Image URL” and “Text” collected from various sites by analyzing Common Crawl data, an open data web crawling project. The collected data (images and text) is subject to the license to which each content belongs.

Obligation to use

While Open Source may be free to use, that does not mean it is free of obligation. To determine whether your intended use of the COYO dataset is suitable for the CC-BY-4.0 license, please consider the license guide. If you violate the license, you may be subject to legal action such as the prohibition of use or claim for damages depending on the use.

Citation Information

Based on the following dataset:

@misc{kakaobrain2022coyo-700m,
  title         = {COYO-700M: Image-Text Pair Dataset},
  author        = {Minwoo Byeon, Beomhee Park, Haecheon Kim, Sungjun Lee, Woonhyuk Baek, Saehoon Kim},
  year          = {2022},
  howpublished  = {\url{https://github.com/kakaobrain/coyo-dataset}},
}

Contributions

  • Don Branson
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