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Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).
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DISCUSSION: We postulate that the rapid onset of hyperglycemia and the resulting medical sequelae were due to olanzapine.
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In all three patients carbamazepine was introduced and gradually increased to a maximum dosage of 25 mg/kg of body weight per day.
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We report three cases of severe hypocalcaemia associated with i.v. bisphosphonate treatment in patients with multiple myeloma.
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Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.
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The viral DNA copy number in whole blood remained positive, however, but was reduced.
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In addition, we emphasize the need for informed consent when facing factors that predispose to bleeding (esophageal varices, coagulopathy and thrombocytopenia), possible band ligation before the start of sorafenib, careful clinical monitoring and discontinuation of sorafenib when major bleeding occurs.
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Although these eight patients had shown various mental, neurological and gastrointestinal symptoms, as well as skin lesions, the diagnosis of pellagra had not been made clinically.
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Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
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Pegylated liposomal doxorubicin (PLD) is a chemotherapeutic agent used in the treatment of solid tumors.
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He died from acute leukaemia.
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The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.
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CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.
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Polymyositis was diagnosed on muscle biopsy.
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METHODS: Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits.
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Six months after the procedure, the patient had an elective angiogram, where we discovered a new severe occlusion distally to the former stent; a second PES was implanted.
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CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.
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Tracheal mucociliary transport velocity (MCTV) was measured by timing the movement of 4 microL of mucus across the trachea.
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A minimum peripheral dose of 36 Gy HDR was administered in 12 fractions (twice a day) at 3 Gy per fraction for a period of 3 days.
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Blood GHB concentrations in the range 156-260 mg/L have been reported to induce moderately sound sleep.
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We discuss our observations in the cases of two patients with acyclovir neurotoxicity and review the findings of all previous reports in the English language literature.
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The patient is healthy 16 months after discontinuation of fluconazole.
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Six months following cessation of therapy, the ERG was still abnormal for one patient, but continued improvement was evident at 25 months; for the second patient, the ERG was normal at one year.
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Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis.
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After clonidine was initiated, the patient's spasticity improved.
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Calculation of this volume from peak and trough levels showed an increase of the volume of distribution during and after chemotherapy.
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The patient exhibited clinical regression and functional improvement.
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Endodontic treatment, when possible, rather than extraction is the treatment of choice in patients suffering from such a disease.
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Disseminated encephalomyelitis in adults.
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This article describes the conservative follow-up of a patient with epidural abscess and diskitis following instrumented posterior lumbar interbody fusion using a metal cage without surgical intervention.
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These signs resolved 24-48 h after cyclosporin and ganciclovir were discontinued.
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A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.
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An alteration in CNS serotonin activity is hypothesized to be the underlying mechanism for several myoclonic syndromes.
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Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.
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Tumour vaccine associated lymphadenopathy and false positive positron emission tomography scan changes.
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Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.
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Electrocardiographic findings and laboratory data indicated a diagnosis of acute myocardial infarction due to the L-thyroxine therapy.
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We describe a patient who developed significant deterioration in her conscious level due to iatrogenic gabapentin overdose.
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We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.
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Their criticisms also differed from a third criticism contained in the article as well as the protocol being advocated in the article, thus contravening the claim that there is one prescribed protocol which must be followed.
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The disorder recurred during treatment with paclitaxel.
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DISCUSSION: NMS is a rare but potentially fatal reaction associated with neuroleptic drugs.
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As with previously reported cases, the condition presents in young women and results in edema of the palms with visibly prominent eccrine ducts after brief exposure to water.
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The cause is believed to be either a hypersensitivity reaction or a toxic dose-related suppression of white blood cell precursors.
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A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.
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Both patients failed to improve after discontinuation of the offending agent, and they responded poorly to corticosteroids.
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Most of the patients had acute leukemia (AL) or related disorders and had received chemotherapy treatment.
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Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine.
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Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.
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We report 3 cases of HIV-1 infected patients who experienced symptomatic angiolipomas shortly after starting antiretroviral therapy including the protease inhibitor indinavir.
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Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT.
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Intractable hypomagnesemia was also a prominent feature.
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The possible pathogenic mechanisms leading to this adverse reaction in this patient are also discussed, and pathophysiologic hypotheses are formulated.
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Only minor complications have been reported previously.
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The in vivo occurrence of such giant forms is rare, and when observed histologically may result in an erroneous diagnosis or a diagnosis of multiple mycotic organisms.
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With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.
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BACKGROUND: Several genetic polymorphisms increase the risk for venous thrombembolism (VTE).
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It is important to always review the medications the patient is taking and consider them as etiological culprits in any new symptom complex.
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The patient's response to the combination of clonazepam and baclofen suggests that the pathophysiology of the "painful legs and moving toes" may be linked to impairment of spinal serotonergic and GABA functions.
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New onset rapid cycling bipolar disorder in an 87 year old woman.
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For the treatment of visual loss, differential diagnosis is important between infection and adverse effect of anti-tuberculous drugs.
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Our patient was a 72-year-old man with advanced Parkinson's disease (PD) who received levodopa and anti-cholinergic drugs and whose head had become almost completely bald.
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In addition, an immediate erythematous macule was observed on the photopatch test site of mequitazine directly after UV exposure which was similar to the immediate erythema noted in chlorpromazine photoallergy.
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These cases indicate that sulpiride can cause tardive dyskinesia and that this drug should be administered with caution.
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CONCLUSION: We believe this to be the first reported case of rhGH-induced hypercalcemia in an HIV-infected patient.
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When a CPS perforates the transverse foramen, even if no apparent VA injury occurs during the operation, the surgeon must take care not to risk cerebral infarction because of an embolism.
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He also experienced improvement in his pain control.
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According to clinical impression some patients showed an improved goal orientation and self-control which could be effects worth to be followed up.
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Titers for Epstein-Barr virus, hepatitis B, toxoplasmosis; and cytomegalovirus were all negative.
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INTRODUCTION: Pamidronate disodium, a bone resorption inhibitor through osteoclast mediation, has been used to treat chronic hypercalcemia secondary to malignancy and chronic renal failure.
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We encountered 2 patients with a psychiatric disorder (depression in one and catatonia in one) accompanied by motor inhibition that was complicated by pulmonary embolism (PE).
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PURPOSE: The aim of this study was to report on the possible development of corneal endothelial deposits resulting from the use of rifabutin.
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Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.
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Both infants continued on medical therapy until they reached 1 month of age.
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A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.
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Further study to confirm this significant finding and to determine if the long term prognosis of BP can be altered by the drug, is required.
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We report the first case of a patient in a promethazine-induced coma responding to treatment with flumazenil.
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A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.
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Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study.
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We concluded that an adequate dose of steroids can be the first line of therapy for PRCA after ABO-mismatched allogeneic stem cell transplantation.
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Fetal exposure to anticonvulsant drugs.
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We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.
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The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.
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With the increasing use of these antimitotic agents, great vigilance should be exercised with regard to renal function and haemolytic status.
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Cholelithiasis in turn enhances the effects of cyclosporin on increased platelet aggregation.
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OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.
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The incidence and clinical features of allergic contact and/or photocontact dermatitis due to psoralens were examined in 371 patients with psoriasis treated with topical PUVA.
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Of note, Compositae dermatitis has been shown to have a higher prevalence in children with atopic dermatitis, so it is important for physicians to be aware of the potential allergens (like bisabolol) in products they are recommending as first line treatments.
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On the next day he died, probably as a result of heart failure.
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Cisplatin toxicity on cardiac electrical activity is discussed.
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Reversal of intractable acute severe asthma by first-trimester termination of pregnancy.
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Indeed, the superiority of the combination of interferon alfa and ribavirin in terms of antiviral action is corroborated by the enhancement of a Th1-type immune reaction by this combination.
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While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.
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This is a case report of possible association of methylphenidate and enuresis in an 11-year-old boy with attention deficit hyperactivity disorder.
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The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.
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Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy.
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We report on two cases in which mother-infant PIVKA concentrations were measured at birth after chronic anticonvulsant therapy during pregnancy.
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This prompted us to suspect that ddI might be responsible for fulminant hepatitis in all three AIDS patients.
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Four months later there were no cells in the anterior chamber and the vitreous was clear.
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However, delayed presentation of flap compromise is an ominous predictor of flap loss.
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